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Pneumococcus, meningococcus, and Haemophilus influenzae cause a similar spectrum of infections in the ear, lung, blood, and brain. They share cross-reactive antigens that bind to the laminin receptor of the blood-brain barrier as a molecular basis for neurotropism, and this step in pathogenesis was addressed in vaccine design.

Broadly Protective Protein-Based Pneumococcal Vaccine Composed of Pneumolysin Toxoid–CbpA Peptide Recombinant Fusion Protein