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Organ dysfunction and tissue hypoxia in severe falciparum malaria result from an imbalance between oxygen delivery and demand. In severe malaria, microvascular obstruction from parasite sequestration decreases oxygen delivery. However, host microvascular function (defined as the capacity to increase oxygen delivery in response to ischemia) and oxygen consumption have not been assessed.

Impaired Skeletal Muscle Microvascular Function and Increased Skeletal Muscle Oxygen Consumption in Severe Falciparum Malaria