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Brain histology and ophthalmoscopy suggest that approximately 25% of children with World Health Organization-defined cerebral malaria (CM) have a nonmalarial cause of death. Misclassification complicates clinical care, confounds studies of association, and may obfuscate successes in malaria control. Retinopathy predicts intracerebral parasite sequestration with &gt;90% sensitivity and specificity, but detecting retinopathy requires well-trained personnel and expensive equipment.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Plasma Concentrations of Parasite Histidine-Rich Protein 2 Distinguish Between Retinopathy-Positive and Retinopathy-Negative Cerebral Malaria in Malawian Children