Open AccessImpact of Fluoroquinolone Resistance Mutations on Gonococcal Fitness and In Vivo Selection for Compensatory Mutations
Author(s) -
Anjali Kunz,
A. A. Begum,
Hong Wu,
Jonathan A. D'Ambrozio,
J. M. Robinson,
William M. Shafer,
Margaret C. Bash,
Ann E. Jerse
Publication year - 2012
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jis277
Subject(s) - neisseria gonorrhoeae , quinolone , mutation , genetics , biology , gonorrhea , selection (genetic algorithm) , antibiotic resistance , neisseriaceae , drug resistance , microbiology and biotechnology , virology , gene , antibiotics , artificial intelligence , computer science , human immunodeficiency virus (hiv)
Quinolone-resistant Neisseria gonorrhoeae (QRNG) arise from mutations in gyrA (intermediate resistance) or gyrA and parC (resistance). Here we tested the consequence of commonly isolated gyrA(91/95) and parC86 mutations on gonococcal fitness.
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