Open AccessEpidemiologic Consequences of Microvariation in Mycobacterium tuberculosis
Author(s) -
Barun Mathema,
Natalia Kurepina,
Guibin Yang,
Elena Shashkina,
Claudia Manca,
Carolina Mehaffy,
Helle BielefeldtOhmann,
Shama D. Ahuja,
Dorothy Fallows,
Angelo Izzo,
Pablo Bifani,
Karen M. Dobos,
Gilla Kaplan,
Barry N. Kreiswirth
Publication year - 2012
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jir876
Subject(s) - biology , tuberculosis , mycobacterium tuberculosis , genotype , genotyping , immune system , immunology , population , virology , chemokine , genetics , medicine , gene , environmental health , pathology
Evidence from genotype-phenotype studies suggests that genetic diversity in pathogens have clinically relevant manifestations that can impact outcome of infection and epidemiologic success. We studied 5 closely related Mycobacterium tuberculosis strains that collectively caused extensive disease (n = 862), particularly among US-born tuberculosis patients.
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