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Influenza transmission in humans remains poorly understood. In particular, the relative contribution of contact, large droplet, and aerosol transmission is unknown. The aims of this proof-of-concept study were to determine whether an experimentally induced influenza infection is transmissible between humans and whether this would form a viable platform for future studies.

Use of a Human Influenza Challenge Model to Assess Person-to-Person Transmission: Proof-of-Concept Study