Open AccessMolecular Characterization of a Streptococcus gallolyticus Genomic Island Encoding a Pilus Involved in Endocarditis
Author(s) -
Camille Danne,
José M. Entenza,
Adeline Mallet,
Romain Briandet,
Michel Débarbouillé,
Farida Nato,
Philippe Glaser,
Grégory Jouvion,
Philippe Moreillon,
Patrick TrieuCuot,
Shaynoor Dramsi
Publication year - 2011
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jir666
Subject(s) - pilin , pilus , biology , microbiology and biotechnology , sortase , bacterial adhesin , virulence , virulence factor , genetics , gene , bacterial protein
Streptococcus gallolyticus is a causative agent of infective endocarditis associated with colon cancer. Genome sequence of strain UCN34 revealed the existence of 3 pilus loci (pil1, pil2, and pil3). Pili are long filamentous structures playing a key role as adhesive organelles in many pathogens. The pil1 locus encodes 2 LPXTG proteins (Gallo2178 and Gallo2179) and 1 sortase C (Gallo2177). Gallo2179 displaying a functional collagen-binding domain was referred to as the adhesin, whereas Gallo2178 was designated as the major pilin.
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