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Background Human leukocyte antigen (HLA) polymorphism influences innate and adaptive immune responses. Among heterosexual couples in the HPV Infection and Transmission among Couples through Heterosexual activity (HITCH) cohort study, we examined whether allele sharing in a couple predicted the partners’ infections with the same HPV-type. Methods We tested genital samples from 271 couples for 36 HPV genotypes by PCR. We used direct DNA-sequencing to type HLA-B07, -DRB1, -DQB1 and –G. Generalized estimating equations were used to examine the associations between the extent of allele sharing and HPV type concordance in which at least one of the partners was HPV positive. Results We identified 106 different HLA-alleles. The most common HLA-alleles among couples were G*01:01:01 (95.6%), G*01:01:02 (60.1%), DQB1*03:01 (57.2%) and DRB1*07:01 (46.9%). Allele sharing was as follows: 19.6% shared none, 43.2% shared one only, 25.1% shared two, and 12.5% shared 3-5. Irrespective of HLA class, grouped or in combination, the extent of allele sharing was not a significant predictor of type-specific HPV concordance in a couple (OR=1.1, 95%CI: 0.5-2.1, for 3-5 vs. none). Conclusion We found no evidence that the extent of HLA-allele concordance influences the likelihood of HPV transmission in newly formed heterosexual couples.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Role of Human Leukocyte Antigen Allele Sharing in Human Papillomavirus Infection Transmission Among Heterosexual Couples: Findings From the HITCH Cohort Study