Open AccessMoraxella catarrhalis in Acute Laryngitis: Infection or Colonization?
Author(s) -
C. Hoi,
Claës Schalén,
C. M. Verduin,
E. E. M. Van Dijke,
J. Verhoef,
A. Fleer,
Johannes van Dijk
Publication year - 1996
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/174.3.636
Subject(s) - moraxella catarrhalis , laryngitis , moraxella (branhamella) catarrhalis , virulence , microbiology and biotechnology , moraxella , pathogenesis , immunology , medicine , biology , bacteria , dermatology , antibiotics , gene , haemophilus influenzae , biochemistry , genetics
The complement phenotypes of Moraxella catarrhalis isolates obtained from adult patients with acute laryngitis were investigated using a microliter serum bactericidal assay and compared with those of other donor groups. Laryngitis isolates had a higher proportion (57%) of complement-resistant strains than did carrier strains from healthy 8- to 13-year-old schoolchildren (16%). The difference between these groups was statistically significant (chi2 [3 x 2 table] = 21.55; P < .001). The relatively frequent occurrence of the complement-resistant (virulence-associated) phenotype in adults with acute laryngitis supports the theory of an active role of M. catarrhalis in the pathogenesis of acute laryngitis.
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