Open AccessEffective Immunization with Live Attenuated Influenza A Virus Can Be Achieved in Early Infancy
Author(s) -
M L Clements,
Mamodikoe Makhene,
Ruth A. Karron,
Brian R. Murphy,
Mark C. Steinhoff,
Kanta Subbarao,
Modena Wilson,
Pediatric Care Center,
Peter F. Wright
Publication year - 1996
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/173.1.44
Subject(s) - immunogenicity , virus , virology , immunization , medicine , hemagglutination assay , titer , antibody , live attenuated influenza vaccine , immunity , infectivity , immunology , attenuated vaccine , biology , influenza vaccine , immune system , virulence , biochemistry , gene
The immunogenicity of vaccines can be modified in infancy by maternal antibodies and other immunizations. Hence, the safety and immunogenicity of two doses of 10(7) TCID50 of live, attenuated cold-adapted (ca) influenza A/Kawasaki/86 (H1N1) reassortant virus vaccine given with or apart from childhood immunizations were evaluated in infants, starting at 2, 4, or > 6 months of age, in randomized, double-blind trials. The ca vaccine was safe and did not significantly reduce the immunogenicity of the childhood vaccines in these infants. Infectivity of ca virus (virus shedding, > or = 4-fold rise in serum hemagglutination inhibition antibody titer, or both) was affected by age, quantity of ca virus given, and prior ca virus infection. Two doses of 10(7) TCID50 of ca influenza virus infected all infants, indicating that both doses are probably needed to achieve immunity against influenza in infants < 6 months of age.
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