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In vivo mapping by positron emission tomography of the serotonin 1A receptors has been hindered by the lack of suitable agonist positron emission tomography probes. 18 F-labeled F13714 is a recently developed biased agonist positron emission tomography probe that preferentially targets subpopulations of serotonin 1A receptors in their "active state," but its brain labeling pattern in nonhuman primate has not been described. In addition, a potential confound in the translatability of PET data between nonhuman animal and human arise from the use of anesthetics that may modify the binding profiles of target receptors.

international journal of neuropsychopharmacology

Marmoset Serotonin 5-HT1AReceptor Mapping with a Biased Agonist PET Probe18F-F13714: Comparison with an Antagonist Tracer18F-MPPF in Awake and Anesthetized States