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A difficult problem in treating opioid addicts is the maintenance of a drug-free state because of the negative emotional symptoms associated with withdrawal, which may trigger relapse. Several lines of evidence suggest a role for the metabotropic glutamate receptor 5 in opioid addiction; however, its involvement during opioid withdrawal is not clear.

international journal of neuropsychopharmacology

Emotional Impairment and Persistent Upregulation of mGlu<sub>5</sub>Receptor following Morphine Abstinence: Implications of an mGlu<sub>5</sub>-MOPr Interaction

Emotional Impairment and Persistent Upregulation of mGlu5Receptor following Morphine Abstinence: Implications of an mGlu5-MOPr Interaction

Emotional Impairment and Persistent Upregulation of mGlu₅Receptor following Morphine Abstinence: Implications of an mGlu₅-MOPr Interaction