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237–42. 37 Freathy RM, Bennett AJ, Ring SM et al. Type 2 Diabetes Risk Alleles are Associated with Reduced Size at Birth. Diabetes 2009;58:1428–33. 38 Dwyer T, Blizzard L, Patterson B. Association between birth weight and adolescent systolic blood pressure in a Caucasian birth cohort differs according to skin type, CRH promoter or 11beta-HSD2 genotype. Arch Dis Child 2008;93:760–67. 39 Weedon MN, Frayling TM, Shields B et al. Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene. Diabetes 2005;54:576–81. 40 Freathy RM, Weedon MN, Bennett A. Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals. Am J Hum Genet 2007;80: 1150–61. 41 Bygren LO, Kaati G, Edvinsson S. Longevity determined by paternal ancestors’ nutrition during their slow growth period. Acta Biotheoretica 2001;49:53–59. 42 Pembrey ME, Bygren LO, Kaati G et al. Sex-specific, maleline transgenerational responses in humans. Eur J Hum Genet 2006;14:159–66.

Commentary: What can evidence on intergenerational transmission of risk of low birth weight and cardiovascular disease tell us about mechanisms?