Open AccessStillbirth and slow metabolizers of caffeine: comparison by genotypes
Author(s) -
Bodil Hammer Bech,
Herman Autrup,
Ellen A. Nøhr,
Tine Brink Henriksen,
Jørn Olsen
Publication year - 2006
Publication title -
international journal of epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.406
H-Index - 208
eISSN - 1464-3685
pISSN - 0300-5771
DOI - 10.1093/ije/dyl116
Subject(s) - caffeine , cyp1a2 , genotype , arylamine n acetyltransferase , glutathione , metabolism , physiology , pharmacogenetics , pharmacology , medicine , cytochrome p450 , biology , chemistry , enzyme , genetics , biochemistry , gene
Cytochrome P4501A2 (CYP1A2) and N-acetyltransferase 2 (NAT2) are key enzymes in the metabolism of caffeine. The polymorphism of these genes facilitates the detection of fast and slow metabolizers, and if caffeine is causally related to stillbirth, we expect slow metabolizers to have a higher risk of stillbirth at any given intake of caffeine. Gluthatione S-transferase alpha1 (GSTA1) may also be active in the metabolism of caffeine as it conjugates glutathione to aromatic amines. Our study, therefore, included analyses of the association between GSTA1 and stillbirth.
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