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Background The purpose of this study was to assess the effect of yoga therapy (YT) on health outcomes of women suffering from polycystic ovary syndrome (PCOS). Interventional studies, with postmenarchal and premenopausal females with PCOS who received YT, with any health outcome reported, were included. Methods Scopus, Cochrane, PubMed, EMBASE and, MEDLINE databases were electronically searched. Systematic review included 11 experimental studies, representing 515 participants with PCOS, out of which 2 randomized controlled trials (RCT’s) were included for meta-analysis. Random effects model was applied using Review Manager Software Version 5.4.1 and strength of evidence was assessed using GRADEpro Guideline Development Tool, 2020. This systematic review and meta-analysis was undertaken according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines and registered with the International Prospective Register of Systematic Reviews (PROSPERO) with registration number CRD42021229619. Results Meta-analysis showed that YT may significantly decrease menstrual irregularity (MD -0.41, 95% CI -0.74 to -0.08), clinical hyperandrogenism (MD -0.70, 95% CI -1.15 to -0.26), fasting blood glucose (FBG) (MD -0.22 mmol/L, 95% CI -0.44 to -0.01), fasting insulin (FI) (MD -28.21 pmol/L, 95% CI -43.79 to -12.63) and HOMA-IR value (MD -0.86, 95% CI -1.29 to -0.43). Strength of evidence was low. Conclusions YT may have beneficial effects on health outcomes in women suffering from PCOS. However, low strength of evidence suggests need of conducting well-designed RCT’s to assess the efficacy of YT for PCOS. Key messages This systematic review and meta-analysis adds to the knowledge about effects of YT on health outcomes of women with PCOS.

1387Effect of yoga therapy on health of women with polycystic ovary syndrome: systematic-review and meta-analysis