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Background Despite the etiology of Kawasaki Disease (KD) remains unknown, identifying spatiotemporal clusters of KD could support its hypothesis to be infectious disease. However, spatiotemporal clusters of KD have never been reported in South Korea. Therefore, this study aims to analyse the spatiotemporal patterns of KD in South Korea using national representative data. Methods We extracted epidemiologic-week (Epi-week) based KD case (ICD-10-CM code, M303) from 2008-2017 national health insurance service data in municipal level. To determine whether spatial autocorrelation and municipal-level clusters exist, year, sex, and age group (&amp;lt;5, 5-9) stratified Global Moran’s I statistics and LISA spatial scan statistics on KD incidence were conducted. Results A total of 98,503 cases of KD were reported in 2008-2017 (aged &amp;lt;5: 72,562 cases [73.7%]). Mean diagnosis age was 4.2±7.0 years, and male-to-female ratio was 1.39:1. Incidence among patients aged &amp;lt;5 increased since 2008; the highest in 2016 (396.78 per 100,000 population). KD had seasonality of winter and summer. Epi-week 46-52 was the most frequent season for cases aged &amp;lt;5, while Epi-week 1-5 was the most frequent season for cases aged 5-9. Positive spatial autocorrelation was consistently reported in every stratum except for ‘2012year/female/age5-9’ and ‘2015year/female/age5-9’ stratum. High-high clusters were consistently detected in the eastern part of South Korea in every stratum. Conclusions South Korea had steady increase in KD incidence since 2008 and municipal-level clusters throughout 2008-2017. Key messages Kawasaki disease in South Korea had spatiotemporal patterns.

1496Spatiotemporal patterns of Kawasaki disease in South Korea: using 2008-2017 national representative data