1268Occupational risk factors for declined kidney function among field and non-field sugarcane workers in Peru

Background Compare the estimated glomerular filtration rate (eGFR) between field and non-field working in the sugar industry, exploring occupational factors associated with eGFR levels. Methods Cross-sectional study performed with workers of a sugar company in San Jacinto, Peru. We compared both groups regarding their eGFR<90 (ml/min/1.73m2) estimated from serum creatinine using the CKD-EPI prediction equation. We analyzed heat stress, vigorous activities and dehydration as risk factors associated with eGFR. We fitted Poisson regression models with robust variance to estimate the prevalence ratio (PR) of eGFR<90 between field and non-field and the association to risk factors. Results We analyzed the data from 137 men, aged 42.3 years (SD = 11.3) on average. Field (57/137, 41.6%) were exposed to higher occupational heat stress (median +0.1 °C), drank 0.7 litres more fluids, and developed more vigorous activities than non-field. The eGFR<90 was more prevalent in field (31.6%) than in non-field (23.6%). After adjusting for occupational factors, the PR between field and non-field was 1.40 (95% CI:0.83-2.37). Occupational heat stress (PR:2.11; 95% CI:1.06-4.22) and age (PR:1.04; 95% CI:1.01-1.08) were associated with a deteriorated renal function (eGFR<90). Conclusions Field had a more deteriorated kidney function compared to non-field. Strenuous work in high-temperature environments and age contribute to reducing the kidney function of field. Occupational interventions focused on these factors can help to reduce the incidence of Chronic Kidney Disease of an undetermined cause among Peruvian fields. Key messages Occupational health; Sugarcane work; CKDu.