Open AccessFlexible mechanoprosthesis made from woven ultra-high-molecular-weight polyethylene fibres: proof of concept in a chronic sheep model
Author(s) -
Amir Basir,
Remco B. Grobben,
Maarten J. Cramer,
Joost A. van Herwaarden,
Aryan Vink,
Gerard Pasterkamp,
Jolanda Kluin,
Paul F. Gründeman
Publication year - 2017
Publication title -
interactive cardiovascular and thoracic surgery
Language(s) - English
Resource type - Journals
eISSN - 1569-9293
pISSN - 1569-9285
DOI - 10.1093/icvts/ivx244
Subject(s) - medicine , histology , connective tissue , mitral valve , regurgitation (circulation) , heart valve , stenosis , calcification , cardiology , surgery , pathology
Ultra-high-molecular-weight polyethylene (UHMWPE) fibres are flexible, have high tensile strength, and platelet and bacterial adhesion is low. Therefore, UHMWPE may overcome limitations of current mechanical valves and bioprostheses. In this study, the biocompatibility and functionality of prototype handmade stented valves from woven UHMWPE (U-valve) was assessed in a chronic sheep model with acetylsalicylic acid monotherapy.
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