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Extracorporeal circulation is associated with ischaemia-reperfusion-induced oxidative stress and atrial fibrillation (AF). Ageing is the major risk factor for this arrhythmia. Reinforcing the antioxidant defence system would be expected to protect the myocardium against ischaemia-reperfusion damage. We studied the effect of antioxidant reinforcement and ageing on the occurrence of postoperative AF.

Ageing improves the antioxidant response against postoperative atrial fibrillation: a randomized controlled trial