Open AccessHuman Intestinal Macrophages Are Involved in the Pathology of Both Ulcerative Colitis and Crohn Disease
Author(s) -
Suranga Dharmasiri,
Eva M. GarridoMartín,
Richard Harris,
Adrian C Bateman,
Jane Collins,
Fraser Cummings,
Tilman Sánchez-Elsner
Publication year - 2021
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1093/ibd/izab029
Subject(s) - ulcerative colitis , inflammatory bowel disease , colitis , immune system , immunology , macrophage , inflammation , paneth cell , crohn's disease , pathogenesis , transcriptome , intestinal mucosa , medicine , biology , pathology , disease , gene expression , gene , small intestine , in vitro , biochemistry
Intestinal macrophages are key immune cells in the maintenance of intestinal immune homeostasis and have a role in the pathogenesis of inflammatory bowel disease (IBD). However, the mechanisms by which macrophages exert a pathological influence in both ulcerative colitis (UC) and Crohn disease (CD) are not yet well understood.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom