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High tech drug delivery systems, which allow for precise location targeting and efficient delivery mechanisms, can reduce the risk of side effects and increase dosage effectiveness in the treatment of Crohn’s disease. We describe a revolutionary capsule technology which uses radiofrequency signaling to trigger an optimal release of the pharmaceutical contents to specified regions of the gastrointestinal tract. System and method Data were observed in two groups of female Yorkshire-Cross swine. Intra-cecal ports were surgically placed in Group 2 swine. After baseline analysis was complete, all study animals were administered the SmartTab capsule (Group 1 administration via balling device, Group 2 administration via intra-cecal port) containing caffeine, barium sulfate, citric acid, and sodium bicarbonate. SmartTab capsules were activated by a radiofrequency triggering event, immediately following administration in Group 2 swine and 30 minutes following administration in Group 1 swine. Blood samples were taken at 0.25, 0.50, 1, 2, 3, and 6 hours after dosing and capsule activation was confirmed using a C-Scan. Results Pharmacokinetic analysis revealed increased caffeine concentrations in the targeted areas. Absorption was significantly higher and more consistent in the cecum targeted administration of the SmartTab compared to the control. Although, caffeine concentrations in the stomach regions were fairly similar amongst both the experimental and control groups. Conclusions Via radiofrequency signaling, the SmartTab capsule can successfully administer active ingredients to the target site. With pre-installed onboard sensors, enabling the devices to send real-time data to physicians and personalize treatments using AI algorithms, this technique holds the potential to generate further advancement in high-tech drug delivery systems. Preparations are currently in order to reapply this technology in the form of an injection capsule. All 6 PK Curves

ADVANCING HIGH TECH DRUG DELIVERY SYSTEMS FOR THE TREATMENT OF CROHN’S DISEASE