Open AccessEstrogen receptor β: the guardian of the endometrium
Author(s) -
D Hapangama,
Areege Mustafa Kamal,
J. N. Bulmer
Publication year - 2014
Publication title -
human reproduction update
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.977
H-Index - 180
eISSN - 1362-4946
pISSN - 1355-4786
DOI - 10.1093/humupd/dmu053
Subject(s) - endometrium , estrogen , estrogen receptor , medicine , endocrinology , gynecology , breast cancer , cancer
The endometrium is the primary target organ for the 'female' sex steroid hormone estrogen, which exerts effects in the endometrium via two main classical estrogen receptor (ER) isoforms, ERα and ERβ. The main function of the endometrium, embryo implantation, appears unperturbed in ERβ knockout mice, which has led researchers to disregard other potentially important functional roles that ERβ may have in endometrium. This review focuses on ERβ in the human endometrium and its protective role from the undesired effects of ERα.
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