Open AccessFunctional relationship between obesity and male reproduction: from humans to animal models
Author(s) -
Katja J. Teerds,
Dirk G. de Rooij,
Jaap Keijer
Publication year - 2011
Publication title -
human reproduction update
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.977
H-Index - 180
eISSN - 1362-4946
pISSN - 1355-4786
DOI - 10.1093/humupd/dmr017
Subject(s) - leptin , obesity , overweight , fertility , infertility , endocrinology , medicine , kisspeptin , leptin receptor , animal studies , hypogonadotropic hypogonadism , biology , population , receptor , hormone , pregnancy , genetics , environmental health
The increase in the incidence of obesity has a substantial societal health impact. Contrasting reports have been published on whether overweight and obesity affect male fertility. To clarify this, we have reviewed published data on the relation between overweight/obesity, semen parameters, endocrine status and human male fertility. Subsequently, we have used results obtained in animal models of obesity to explain the human data.
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