Open AccessMitochondrial DNA transmission, replication and inheritance: a journey from the gamete through the embryo and into offspring and embryonic stem cells
Author(s) -
Justin C. St. John,
João Facucho-Oliveira,
Yan Jiang,
Richard D. Kelly,
Rachida Salah
Publication year - 2010
Publication title -
human reproduction update
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.977
H-Index - 180
eISSN - 1362-4946
pISSN - 1355-4786
DOI - 10.1093/humupd/dmq002
Subject(s) - biology , mitochondrial dna , genetics , embryonic stem cell , somatic cell , stem cell , microbiology and biotechnology , oocyte , blastocyst , embryo , embryogenesis , gene
Mitochondrial DNA (mtDNA) encodes key proteins associated with the process of oxidative phosphorylation. Defects to mtDNA cause severe disease phenotypes that can affect offspring survival. The aim of this review is to identify how mtDNA is replicated as it transits from the fertilized oocyte into the preimplantation embryo, the fetus and offspring. Approaches for deriving offspring and embryonic stem cells (ESCs) are analysed to determine their potential application for the prevention and treatment of mtDNA disease.
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