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The selective progesterone receptor modulator asoprisnil suppresses uterine bleeding and decreases leiomyoma volume while maintaining follicular phase estrogen concentrations. For safety of potential clinical applications, any proliferative effect of asoprisnil on uterine tissues, particularly endometrium, needs to be established.

Effect of asoprisnil on uterine proliferation markers and endometrial expression of the tumour suppressor gene, PTEN