English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

The hippocampus is a key brain region for memory formation. Metabotropic glutamate type 5 receptors (mGlu 5 R) are strongly expressed in CA1 pyramidal neurons and fine-tune synaptic plasticity. Accordingly, mGlu 5 R pharmacological manipulation may represent an attractive therapeutic strategy to manage hippocampal-related neurological disorders. Here, by means of a membrane yeast two-hybrid screening, we identified contactin-associated protein 1 (Caspr1), a type I transmembrane protein member of the neurexin family, as a new mGlu 5 R partner. We report that mGlu 5 R and Caspr1 co-distribute and co-assemble both in heterologous expression systems and in rat brain. Furthermore, downregulation of Caspr1 in rat hippocampal primary cultures decreased mGlu 5 R-mediated signaling. Finally, silencing Caspr1 expression in the hippocampus impaired the impact of mGlu 5 R on spatial memory. Our results indicate that Caspr1 plays a pivotal role controlling mGlu 5 R function in hippocampus-dependent memory formation. Hence, this new protein–protein interaction may represent novel target for neurological disorders affecting hippocampal glutamatergic neurotransmission.

Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation