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The genetic architecture of adolescent idiopathic scoliosis (AIS) remains poorly understood. Here we present the result of a 4-stage genome-wide association study composed of 5,953 AIS patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near  MEIS1  (P combined  = 1.19 × 10 −13 , OR = 1.21, 95% CI = 1.10–1.32), rs7633294 at 3p14.1 near  MAGI1  (P combined  = 1.85 × 10 −12 , OR = 1.20, 95% CI = 1.09–1.32), and rs9810566 at 3q26.2 near  TNIK  (P combined  = 1.14 × 10 −11 , OR = 1.19, 95% CI = 1.08-1.32). We also confirmed a recently reported region associated with AIS at 20p11.22 (P combined  = 1.61 × 10 −15 , OR = 1.22, 95% CI = 1.12–1.34). Furthermore, we observed significantly asymmetric expression of  Wnt/beta-catenin  pathway in the bilateral paraspinal muscle of AIS patients, including  beta-catenin, TNIK,  and  LBX1 . This is the first study that unveils the potential role of  Wnt/beta-catenin  pathway in the development of AIS, and our findings may shed new light on the etiopathogenesis of AIS.

human molecular genetics

Genome-wide association study identifies novel susceptible loci and highlights  Wnt/beta-catenin  pathway in the development of adolescent idiopathic scoliosis