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Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by  in silico  and  de novo  replication among 7488–47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the  KCNQ1  (rs2237892,  P  = 9.29 × 10 −13 ),  ALDH2/MYL2  (rs671,  P  = 3.40 × 10 −11 ; rs12229654,  P  = 4.56 × 10 −9 ),  ITIH4  (rs2535633,  P  = 1.77 × 10 −10 ) and  NT5C2  (rs11191580,  P  = 3.83 × 10 −8 ) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level ( P  &lt; 5.0 × 10 −8 ) and an additional 14 at  P  &lt; 1.0 × 10 −3  with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index