English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Long non-coding RNAs (lncRNAs) have been recently found to be pervasively transcribed in human genome and link to diverse human diseases. However, the expression patterns and regulatory roles of lncRNAs in hematopoietic malignancies have not been reported. Here, we carried out a genome-wide lncRNA expression study in  MLL -rearranged acute lymphoblastic leukemia ( MLL -r ALL) and established lncRNA/messenger RNA coexpression networks to gain insight into the biological roles of these dysregulated lncRNAs. We detected a number of lncRNAs that were differentially expressed in  MLL -r ALL samples compared with  MLL -r wild-type and identified unique lncRNA expression patterns between  MLL -r subtypes with different translocations as well as between infant  MLL -r ALL with other  MLL -r ALL patients, suggesting that they might be served as novel biomarkers for the disease. Importantly, several lncRNAs that correspond with membrane protein genes, including a lysosome-associated membrane protein, were identified. No such link between the membrane proteins and  MLL -r leukemia has been reported previously. Impressively, the functional analysis showed that several lncRNAs corresponded to the expression of MLL-fusion protein target genes, including  HOXA9 ,  MEIS1 , etc., while some other associated with histone-related functions or membrane proteins. Further experiments characterize the effect of some lncRNAs on  MLL -r leukemia apoptosis and proliferation as the function of the coexpressed  HOXA  gene cluster. Finally, a set of lncRNAs epigenetically regulated by H3K79 methylation were also discovered. These findings may provide novel insights into the mechanisms of lncRNAs involved in the initiation of  MLL -r leukemia. This is the first study linking lncRNAs to leukemogenesis.

A distinct set of long non-coding RNAs in childhood MLL -rearranged acute lymphoblastic leukemia: biology and epigenetic target