English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Increased systemic levels of myeloperoxidase (MPO) are associated with the risk of coronary artery disease (CAD). To identify the genetic factors that are associated with circulating MPO levels, we carried out a genome-wide association study (GWAS) and a gene-centric analysis in subjects of European ancestry and African Americans (AAs). A locus on chromosome 1q31.1 containing the complement factor H ( CFH ) gene was strongly associated with serum MPO levels in 9305 subjects of European ancestry (lead SNP rs800292;  P  = 4.89 × 10 −41 ) and in 1690 AA subjects (rs505102;  P  = 1.05 × 10 −8 ). Gene-centric analyses in 8335 subjects of European ancestry additionally identified two rare  MPO  coding sequence variants that were associated with serum MPO levels (rs28730837,  P  = 5.21 × 10 −12 ; rs35897051,  P  = 3.32 × 10 −8 ). A GWAS for plasma MPO levels in 9260 European ancestry subjects identified a chromosome 17q22 region near  MPO  that was significantly associated (lead SNP rs6503905;  P  = 2.94 × 10 −12 ), but the  CFH  locus did not exhibit evidence of association with plasma MPO levels. Functional analyses revealed that rs800292 was associated with levels of complement proteins in serum. Variants at chromosome 17q22 also had pleiotropic  cis  effects on gene expression. In a case–control analysis of ∼80 000 subjects from CARDIoGRAM, none of the identified single-nucleotide polymorphisms (SNPs) were associated with CAD. These results suggest that distinct genetic factors regulate serum and plasma MPO levels, which may have relevance for various acute and chronic inflammatory disorders. The clinical implications for CAD and a better understanding of the functional basis for the association of  CFH  and  MPO  variants with circulating MPO levels require further study.

Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia