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Aiming to identify novel genetic loci for pigmentation and skin cancer, we conducted a series of genome-wide association studies on hair color, eye color, number of sunburns, tanning ability and number of non-melanoma skin cancers (NMSCs) among 10 183 European Americans in the discovery stage and 4504 European Americans in the replication stage (for eye color, 3871 males in the discovery stage and 2496 males in the replication stage). We targeted novel chromosome regions besides the known ones for replication. As a result, we identified a new region downstream of the  EDNRB  gene on 13q22 associated with hair color and the strongest association was the single-nucleotide polymorphism (SNP) rs975739 ( P  = 2.4 × 10 −14 ;  P  = 5.4 × 10 −9  in the discovery set and  P  = 1.2 × 10 −6  in the replication set). Using blue, intermediate (including green) and brown eye colors as co-dominant outcomes, we identified the SNP rs3002288 in  VASH2  on 1q32.3 associated with brown eye ( P  = 7.0 × 10 −8 ;  P  = 5.3 × 10 −5  in the discovery set and  P  = 0.02 in the replication set). Additionally, we identified a significant interaction between the SNPs rs7173419 and rs12913832 in the  OCA2  gene region on brown eye color ( P -value for interaction = 3.8 × 10 −3 ). As for the number of NMSCs, we identified two independent SNPs on chr6 and one SNP on chromosome 14: rs12203592 in  IRF4  ( P  = 7.2 × 10 −14 ;  P  = 1.8 × 10 −8  in the discovery set and  P  = 6.7 × 10 −7  in the replication set), rs12202284 between  IRF4  and  EXOC2  ( P  = 5.0 × 10 −8 ;  P  = 6.6 × 10 −7  in the discovery set and  P  = 3.0 × 10 −3  in the replication set) and rs8015138 upstream of  GNG2  ( P  = 6.6 × 10 −8 ;  P  = 5.3 × 10 −7  in the discovery set and  P  = 0.01 in the replication set).

Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans