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Polymorphisms in theMYH9and adjacentAPOL1gene region demonstrate a strong association with non-diabetic kidney disease in African-Americans. However, it is not known to what extent these polymorphisms are present in other ethnic groups. To examine the association of genetic polymorphisms in this region with chronic kidney disease (CKD; estimated glomerular filtration rate &lt;60 ml/min/1.73 m2) in individuals of European ancestry, we examined rs4821480, anMYH9single-nucleotide polymorphism (SNP) recently identified as associated with kidney disease in African-Americans, in 13 133 participants from the Framingham Heart Study (FHS) and Atherosclerosis Risk in Communities (ARIC) Study. In addition, we further interrogated theMYH9/APOL1gene region using 282 SNPs for association with CKD using age-, sex- and center-adjusted models and performed a meta-analysis of the results from both studies. Because of prior data linking rs4821480 and kidney disease, we used aP-value of &lt;0.05 to test the association with CKD. In the meta-analysis, rs4821480 (minor allele frequency 4.45 and 3.96% in FHS and ARIC, respectively) was associated with higher CKD prevalence in participants free of diabetes (odds ratio 1.44; 95% confidence interval 1.15–1.80;P= 0.001). No other SNPs achieved significance after adjusting for multiple testing. Results utilizing directly genotyped data confirmed the results of the primary analysis. Recently identifiedAPOL1risk variants were also directly genotyped, but did not account for the observedMYH9signal. These data suggest that theMYH9polymorphism rs4821480 is associated with an increased risk of non-diabetic CKD in individuals of European ancestry.

The MYH9/APOL1 region and chronic kidney disease in European-Americans