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A strong association betweenERAP1and ankylosing spondylitis (AS) was recently identified by the Wellcome Trust Case Control Consortium and the Australo-Anglo-American Spondylitis Consortium (WTCCC-TASC) study.ERAP1is highly polymorphic with strong linkage disequilibrium evident across the gene. We therefore conducted a series of experiments to try to identify the primary genetic association(s) withERAP1. We replicated the original associations in an independent set of 730 patients and 1021 controls, resequencedERAP1to define the full extent of coding polymorphisms and tested all variants in additional association studies. The genetic association withERAP1was independently confirmed; the strongest association was with rs30187 in the replication set (P= 3.4 × 10−3). When the data were combined with the original WTCCC-TASC study the strongest association was with rs27044 (P= 1.1 × 10−9). We identified 33 sequence polymorphisms inERAP1, including three novel and eight known non-synonymous polymorphisms. We report several new associations between AS and polymorphisms distributed acrossERAP1from the extended case–control study, the most significant of which was with rs27434 (P= 4.7 × 10−7). Regression analysis failed to identify a primary association clearly; we therefore used data from HapMap to impute genotypes for an additional 205 non-coding SNPs located within and adjacent toERAP1. A number of highly significant associations (P&lt; 5 × 10−9) were identified in regulatory sequences which are good candidates for causing susceptibility to AS, possibly by regulatingERAP1expression.

Investigating the genetic association between ERAP1 and ankylosing spondylitis