English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the zaia usage as premium feature

ZAIA

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the access of premium content as premium feature

Premium Content

Zendy Tools

Zendy Open

Apolipoprotein E (APOE) is a major protein in lipid metabolism existing in three common isoforms: APOE2, -3 and -4. The ε4 allele of the APOE gene ( APOE ) coding for the APOE4 isoform is associated with an increased risk of myocardial infarction (MI) and of Alzheimer’s disease (AD). Recently, several polymorphisms in the  APOE  regulatory region have been reported. Some of these have been associated with AD and modified  APOE  allelic mRNA expression in AD brains. Here, we have investigated whether three of these promoter polymorphisms (–491AT, –427CT and –219GT) can also modify cardiovascular risk. The hypothesis was tested in a large multicentre case–control study of MI, the ECTIM Study, on 567 cases and 678 controls. Among the three  APOE  promoter polymorphisms tested, only the  – 219T allele was associated with a significantly increased risk of MI (OR = 1.29, 95% CI: 1.09–1.52,  P  &lt; 0.003) and the effect was shown to be independent of the presence of the other mutations, including the  APOE  ε2/ε3/ε4 polymorphism. Moreover, the  – 219T allele greatly decreased the APOE plasma concentrations in a dose-dependent manner ( P  &lt; 0.008). These data indicate that the  – 219GT polymorphism of the  APOE  regulatory region emerges as a new genetic susceptibility risk factor for MI and constitutes another common risk factor for both neurodegenerative and cardiovascular diseases.

human molecular genetics

Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations—the ECTIM Study