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RBM is an RNA-binding protein encoded on the Y chromosome in mammals and is expressed only in the nuclei of male germ cells. Genetic evidence from infertile men implicates it in spermatogenesis, but its function is unknown. Of a number of potential partners for RBM identified by a yeast two-hybrid screen with testis cDNA, the most frequent isolates encoded a novel RNA-binding protein, termed  T-STAR , that is closely related to SAM68, an Src-associated protein of unknown function. The mouse homologue was also cloned and designated  étoile . It mapped to chromosome 15, while  T-STAR  mapped to the syntenic region on human chromosome 8.  T-STAR/étoile is expressed primarily in the testis; in rat germ cells, the expression of both  T-STAR/étoile  and  SAM68  is regulated during meiosis. Transfection of  T-STAR/étoile  fused with green fluorescent protein into HeLa cells caused an accumulation of protein in a novel compartment of the nucleus, adjacent to the nucleolus but distinct from the perinucleolar compartment. RBM and other hnRNP G family members are candidate downstream targets for regulation by T-STAR/ÉTOILE and SAM68.

T-STAR/ÉTOILE: A Novel Relative of SAM68 That Interacts with an RNA-Binding Protein Implicated in Spermatogenesis