English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

The human gene  HIC1  (hypermethylated in cancer) maps to chromosome 17p13.3 and is deleted in the contiguous gene disorder Miller-Dieker syndrome (MDS) [Makos-Wales  et al . (1995)  Nature Med ., 1, 570–577; Chong  et al  (1996)  Genome Res ., 6, 735–741]. We isolated the murine homologue  Hic1,  encoding a zinc-finger protein with a poxvirus and zinc-finger (POZ) domain and mapped it to mouse chromosome 11 in a region exhibiting conserved synteny to human chromosome 17. Comparison of genomic and cDNA sequences predicts two exons for the murine  Hic1 . The second exon exhibits 88% identity to the human  HIC1  on DNA level. During embryonic development,  Hic1  is expressed in mesenchymes of the sclerotomes, lateral body wall, limb and cranio-facial regions embedding the outgrowing peripheral nerves during their differentiation. During fetal development,  Hic1  additionally is expressed in mesenchymes apposed to precartilagi-nous condensations, at many interfaces to budding epithelia of inner organs, and weakly in muscles. We observed activation of  Hic1  expression in the embryonic anlagen of many tissues displaying anomalies in MDS patients. Besides lissencephaly, MDS patients exhibit facial dysmorphism and frequently additional birth defects, e.g. anomalies of the heart, kidney, gastrointestinal tract and the limbs (OMIM 247200). Thus,  HIC1  activity may correlate with the defective development of the nose, jaws, extremities, gastrointestinal tract and kidney in MDS patients.

Isolation and Embryonic Expression of the Novel Mouse Gene Hic1 , the Homologue of HIC1 , a Candidate Gene for the Miller-Dieker Syndrome