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Here we describe the cloning of the human  Achaete Scute  Homologue 2 ( HASH2 ) gene, officially designated  ASCL2 (Achaete Scute  complex like 2), a homologue of the  DrosophilaAchaete  and  Scute  genes. In mouse, this gene is imprinted and maps to chromosome 7. We mapped the human homologue close to  IGF2  and H19 at 11p15.5, the human region syntenic with mouse chromosome 7, indicating that this imprinted region is highly conserved in mouse and man.  HASH2  is expressed in the extravillus trophoblasts of the developing placenta only. The lack of  HASH2  expression in non-malignant hydatidiform (androgenetic) moles indicates that  HASH2  is also imprinted in man.

The Human Achaete-Scute Homologue 2 (ASCL2, HASH2) Maps to Chromosome 11p15.5, Close to IGF2 and is Expressed in Extravillus Trophoblasts