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The initiation of X-chromosome inactivation in female mammals is controlled by a key locus, the X-inactivation centre (Xic). The  Xist  gene, which maps to the candidate region for Xic and is expressed exclusively from the inactive X chromosome, is thought to be an essential component of the Xic. To test whether sequences spanning several hundred kilobases and including  Xist  from the Xic region are capable of initiating inactivation, we have created a series of transgenic mice using a 460 kb yeast artificial chromosome (YAC). Analysis in these mice of the expression of  Xist , of a  LacZ reporter gene and of two genes in the region that are normally silent on the inactive X chromosome, suggests that essential sequences for  Xist  expression and X-inactivation may be absent in these transgenic animals.

Transgenic Mice Carrying an Xist -Containing YAC