Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate–carbohydrate interactions | Zendy

Marit Sletmoen | Zendy; Thomas Gerken | Zendy; Bjørn T. Stokke | Zendy; Joy Burchell | Zendy; C. Fred Brewer | Zendy

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Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate–carbohydrate interactions

Author(s) -

Marit Sletmoen,

Thomas Gerken,

Bjørn T. Stokke,

Joy Burchell,

C. Fred Brewer

Publication year - 2018

Publication title -

glycobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.757

H-Index - 128

eISSN - 1460-2423

pISSN - 0959-6658

DOI - 10.1093/glycob/cwy032

Subject(s) - glycome , carbohydrate , glycan , carcinogenesis , carbohydrate metabolism , biochemistry , antigen , mucin , chemistry , biology , glycoprotein , cancer research , gene , immunology

The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate-carbohydrate interactions, CCIs) of Tn (Tn-Tn) and STn (STn-STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, which may participate in oncogenesis.

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