Open AccessMemory Resilience to Alzheimer’s Genetic Risk: Sex Effects in Predictor Profiles
Author(s) -
Kirstie L. McDermott,
G. Peggy McFall,
Shea J. Andrews,
Kaarin J. Anstey,
Roger A. Dixon
Publication year - 2016
Publication title -
the journals of gerontology series b
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.578
H-Index - 150
eISSN - 1758-5368
pISSN - 1079-5014
DOI - 10.1093/geronb/gbw161
Subject(s) - clusterin , apolipoprotein e , psychology , psychological resilience , episodic memory , clinical psychology , alzheimer's disease , poisson regression , developmental psychology , risk factor , demography , gerontology , disease , cognition , medicine , biology , genetics , psychiatry , population , apoptosis , psychotherapist , sociology
Apolipoprotein E (APOE) ɛ4 and Clusterin (CLU) C alleles are risk factors for Alzheimer's disease (AD) and episodic memory (EM) decline. Memory resilience occurs when genetically at-risk adults perform at high and sustained levels. We investigated whether (a) memory resilience to AD genetic risk is predicted by biological and other risk markers and (b) the prediction profiles vary by sex and AD risk variant.
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