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Several reports have shown an association between homocysteine, cognitive functioning, and survival among the oldest-old. Two common polymorphisms in the genes coding for methylenetetrahydrofolate reductase (MTHFR 677C&gt;T) and methionine synthase (MTR 2756A&gt;G) have an impact on plasma homocysteine level.

the journals of gerontology. series a, biological sciences and medical sciences

Methylenetetrahydrofolate Reductase 677C&gt;T and Methionine Synthase 2756A&gt;G Mutations: No Impact on Survival, Cognitive Functioning, or Cognitive Decline in Nonagenarians