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Repeated administration of low-molecular-weight heparin (LMWH) to elderly patients with an impaired renal function may lead to an accumulation effect with an increased risk of bleeding. In this setting, Cockcroft-Gault (CG) is the most widely used formula for glomerular filtration rate (GFR) estimation. In hospitalized patients over the age of 70, the six-variable Modification of Diet in Renal Disease (MDRD) formula was compared with the CG formula to detect patients with renal impairment who are at higher risk of bleeding when treated with LMWH.

the journals of gerontology. series a, biological sciences and medical sciences

Is Modification of Diet in Renal Disease Formula Similar to Cockcroft-Gault Formula to Assess Renal Function in Elderly Hospitalized Patients Treated With Low-Molecular-Weight Heparin?