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Longevity can be regarded as a multifactorial trait that results from an interaction between environmental factors and sets of epistatic alleles that have pleiotropic age-dependent effects. The Hotan district in the Xin Jiang Uighur Autonomous region of China is relatively isolated and is well known for an ethnic group that displays marked longevity.

Angiotensin-Converting Enzyme Gene and Longevity in the Xin Jiang Uighur Autonomous Region of China: An Association Study