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The Podospora anserina premature death syndrome was described as early growth arrest caused by a site-specific deletion of the mitochondrial genome (mtDNA) and occurring in strains displaying the genotype AS1-4 mat-. The AS1-4 mutation lies in a gene encoding a cytosolic ribosomal protein, while mat- is one of the two forms (mat- and mat+) of the mating-type locus. Here we show that, depending on culture conditions, death due to the accumulation of the deleted mtDNA molecule can occur in the AS1-4 mat+ context and can be delayed in the AS1-4 mat- background. Furthermore, we show that premature death and the classical senescence process are mutually exclusive. Several approaches permit the identification of the mat-linked gene involved in the appearance of premature death. This gene, rmp, exhibits two natural alleles, rmp- linked to mat- and rmp+ linked to mat+. The first is probably functional while the second probably carries a nonsense mutation and is sporadically expressed through natural suppression. A model is proposed that emphasizes the roles played by the AS1-4 mutation, the rmp gene, and environmental conditions in the accumulation of the deleted mitochondrial genome characteristic of this syndrome.

genetics

Premature Death in <i>Podospora anserina:</i> Sporadic Accumulation of the Deleted Mitochondrial Genome, Translational Parameters and Innocuity of the Mating Types

Premature Death in Podospora anserina: Sporadic Accumulation of the Deleted Mitochondrial Genome, Translational Parameters and Innocuity of the Mating Types