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Biopsy of the ampulla of Vater may be performed to evaluate for ampullary adenomas, suspected ampullary tumors and immunohistological staining for autoimmune pancreatitis. Ampullary biopsies are commonly performed at the time of endoscopic retrograde cholangiopancreatography (ERCP). Due to the well-established complication rate following ERCP, the contribution of ampullary biopsy as a potential independent risk factor would require a controlled comparison.

gastroenterology report

Endoscopic retrograde cholangiopancreatography with ampullary biopsy<i>vs</i>ERCP alone: a matched-pairs controlled evaluation of outcomes and complications

Endoscopic retrograde cholangiopancreatography with ampullary biopsyvsERCP alone: a matched-pairs controlled evaluation of outcomes and complications