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Most medicines are taken by the elderly because they suffer natural changes, which lead to chronic and degenerative diseases. Older people often have increasingly complex medication regimens, which may lead to errors with dosing and administration and to non-adherence to therapy. Non-adherence to therapy leads to a decrease in therapeutic efficacy, an increase in morbidity, suffering, and health costs. It is influenced by several factors that can and should be driven to improve health status. Objectives The objective of this study was to determine and evaluate the medication regimen complexity in an elderly population, in Tábua, and verify its relation with adherence to therapy. Methodology Surveys were applied to elderly people in order to collect the medication data. The study lasted for 5 months and took place at a pharmacy (n = 337). Only people with ≥65 years were included. Medication regimen complexity was assessed using the Brazilian translation for the Medication Regimen Complexity Index (MRCI) and adhesion to therapy was measured by MAT scale. Data was analysed with SPSS statistical program, version 24.0. Results Our study showed a high percentage of adhesion to therapy (65%) and also of polypharmacy among the elderly (84,9%). Most medication that elderly take belong to the cardiovascular system pharmaceutical group (94,1%). Still, people described some difficulties to adhesion to therapy, mainly forgetfulness (73,66%). Data also revealed that individuals with more literacy and those who are not under polypharmacy showed more adherence to therapy (p = 0.000 and p = 0.012). The most significant result from our study was that MRCI and non-adherence are correlated statistically, that is, a higher MRCI leads to an increase in non-adherence to therapy (p = 0.001). Conclusion Healthcare professionals should be aware that high levels of medication regimen complexity suggest bad outcomes and non-adherence to therapy. They should assist the elderly, help avoid errors, and find solutions to improve adherence to therapy, whenever possible.

Non-adhesion to therapy in the elderly, in Tábua