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Hypertrophic cardiomyopathy (HCM) mainly results from autosomal-dominant inherited single heterozygous mutations in cardiac sarcomere genes. Contributions of multiple gene mutations to disease heterogeneity in a three-generation family were investigated.

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Dual LQT1 and HCM phenotypes associated with tetrad heterozygous mutations inKCNQ1,MYH7,MYLK2, andTMEM70genes in a three-generation Chinese family