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editorial refers to ‘Non-vitamin K antagonist oral anticoagulants: considerations on once- vs. twice-daily regimens and their potential impact on medication adherence’ by B. Vrijens and H. Heidbuchel, on page 514–523. This editorial refers to ‘Drug persistence with rivaroxaban therapy in atrial fibrillation patients—results from the Dresden non-interventional oral anticoagulation registry’ by J. Beyer-Westendorf et al. , on page 530–538. For adequate stroke prevention, most patients with non-valvular atrial fibrillation (AF) would need oral anticoagulant therapy (OAC), with either vitamin-K antagonists (VKAs) or non-vitamin-K oral anticoagulants (NOACs).1 Once AF has been diagnosed (which itself may be challenging2,3), the very first priority is effective stroke prevention based on guidelines, but physiciansu0027 adherence to the guidelines for AF management is still suboptimal.4–7 Indeed, guideline adherent therapy is associated with better outcomes.5 An equally important step is the patientu0027s actual uptake of recommended therapy, as well as good adherence and persistence to long-term treatment, which makes the patient a key proactive part of the process.6Current AF guidelines mandate discussion with patients about their values and treatment preferences.1 In order to reach an informed decision about treatment acceptance …

Optimizing stroke prevention in atrial fibrillation: better adherence and compliance from patients and physicians leads to better outcomes