English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Funding Acknowledgements Type of funding sources: None. The aim of the study is to determine predictors of life-threatening arrhythmic events in order to identify high-risk patients requiring ICD/CRT-D implantation. Methods. The study included 155 patients with left ventricular non-compaction cardiomyopathy (NCСM), 59 (38.1%) women, 96 (61.9%) men, and a median age of 39 (28; 51) years. In addition to the standard examination, cardiac magnetic resonance (CMR) imaging with late gadolinium enhancement (LGE) was performed. The median follow-up was 36 months (6; 152). Endpoints of the study included life-threatening arrhythmic events (sustained VT/VF) requiring device implantation (ICD/CRT-D). Results. The most frequent types of arrhythmia were ventricular premature beats (VPB) &amp;gt;500 per day – in 64 (41.3%) pts, nonsustained ventricular tachycardia (VT) was observed in 54 (34.8%) pts, sustained VT – in 15 (9.7%) pts and permanent atrial fibrillation (AF) with episodes of nonsustained VT – in 34 (21.9%) pts. Syncope was recorded in 17 (11%) pts. Symptoms of NYHA FC III CHF were found in 28 (18.1%) pts. According to EchoCG data, the median LV ejection fraction (LVEF) was 44% (34; 54). According to LGE-CMR, 72 (46.8%) pts showed areas of myocardial fibrosis; the median volume of myocardial fibrosis was 13.2% (0.6; 58.5). During the follow-up period, life-threatening arrhythmic events (sustained VT/VF) developed in 15 pts, among which ICD – 8 and CRT-D – 7 were implanted as part of the secondary prevention of sudden cardiac death (SCD). The 3-year event-free survival rate was 88 ± 14%. In multivariate analysis, independent factors associated with the risk of life-threatening events requiring ICD/CRT-D implantation are the following characteristics: the presence of syncope (HR 12.5; 95% CI 3.9–39.7, p &amp;lt; 0.001), the presence of nonsustained VT (HR 11.8; 95% CI 1.5–95.1, p &amp;lt; 0.021) and the percentage of fibrosis volume ≥30% (HR 3.23; 95% CI 1.01–10.4, p &amp;lt; 0.048). Risk groups of life-threatening events were stratified based on multi-factor analysis. The three-year event-free survival rate of the high-risk group was 77.8 ± 5.8%, the low-risk group had no adverse events during the entire follow-up period, and the three-year event-free survival rate was 100%. Conclusion. The developed model of risk stratification of life-threatening events allows identifying high-risk patients for timely preventive measures.

europace

Left ventricular non-compaction cardiomyopathy: additional predictors of life-threatening events for selecting patients for cardioverter-defibrillator implantation