English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Funding Acknowledgements Type of funding sources: None. Background The single procedure success rates of durable pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (AF) varies between 80 and 90 %. This prospective, randomized study investigated the efficacy of Cryo-Balloon PVI versus pulmonary vein isolation with RF-energy following the CLOSE protocol (ablation index (AI), interlesion distance ≤ 6 mm, surround flow catheter) in terms of single-procedure arrhythmia-free outcome, safety and procedural time. Methods and results A total number of 150 patients undergoing de-novo catheter ablation for paroxysmal AF were randomized to two different treatment arms in a 1:1 fashion. In group-A patients, PVI was performed with the 23 or 28 mm Cryo-Balloon (Articfront Balloon, Medtronic Inc). The ablation procedure in group B was performed with RF-energy, using AI and following the CLOSE protocol. During a mean follow-up of 15 ± 6 months after a single procedure, 69 (92%) patients of group A were free of arrhythmia recurrence versus 68 (90.67%) patients in group B (p = ns). A total of 10 patients (group A: 4, group B: 6; p = ns) underwent a redo-procedure. No difference between both groups was observed in terms of patients with PV recovery (group A: 2 (2,67%) vs. group B: 3 (4%); p = ns). In 2 patients of group A and 3 patients of group B the PVs were durably isolated. Two patients of each group had continued paroxysmal AF but did not undergo redo-procedure. Significantly more patients of group A experienced AF recurrence during blanking period, whereas the outcome after 6 month showed no significant differences (group A 11 (14,66%), group B: 6 (8%); p&amp;lt; 0.05). With regard to the procedural data, the procedure time was significantly shorter in group A (115.35 ± 15.38 versus 70.53 ± 16.13; p &amp;lt; 0.01), the flouroscopy time and dose area product showed no significant differences (Table 1). Both procedures were performed with a low number of complications, in group A two patients had a significant groin hematoma, no PE.  Conclusions Cryo-Balloon PVI and PVI using ablation index following the CLOSE protocol are equally efficient in achieving durable PV-isolation. Approximately 7 % of the patients with clinically paroxysmal AF are having extra-pulmonary vein AF sources. Cryo-Balloon ablation leads to significantly more AF recurrence during the blanking period. Procedural data Cryo-Balloon(group A) Ablation Index(group B) p-value Proc. Time (min) 70.53 ± 16.13 115.35 ± 15.38 &amp;lt;0,01 Fluoro time (min) 8.56 ± 3.18 9.66 ± 3.86 0,06 Dose Area Product(cGy/m2) 390.34 ± 268.57 330.84 ± 150.36 0,10

europace

Pulmonary vein isolation using Cryo Balloon ablation versus RF ablation using ablation index following the CLOSE protocol: a Prospective Randomized Trial